One-pot sequential multicomponent route to 2,4-diaminothiazoles—a facile approach to bioactive agents for cancer therapeutics

A facile one-pot sequential three-component route to 2,4-diaminothiazoles is reported. The new approach employs the mildest reaction conditions and commercially available reagents to generate diverse 2-alkyl/arylamino-4-amino-5-aroyl/heteroylthiazoles in short reaction times, good yield, and purity.