Title of article :
Total synthesis of the aromatase inhibitor dihydroisocoumarin via protective opening of lactones
Author/Authors :
Chanti Babu، نويسنده , , D. and Bhujanga Rao، نويسنده , , Ch. and Ramesh Babu، نويسنده , , D. and Raghavendra Swamy، نويسنده , , S. and Venkateswarlu، نويسنده , , Y.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Asymmetric total synthesis of a dihydroisocoumarin, (3R,4R)-(−)-6-methoxy-1-oxo-3-pentyl-3,4-dihydro-1H-isochromen-4-yl acetate (1) starting from commercially available m-anisic acid is described. Herein, we depict the use of protective opening of lactones and construction of δ lactone. The synthesis involves Wittig, Grubbs cross metathesis, and Sharpless dihydroxylation reactions.
Keywords :
Grubbs cross metathesis , Wittig , Dihydroisocoumarin , Xyris pterygoblephara , Sharpless dihydroxylation and lactonization
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
