Author/Authors :
Kim، نويسنده , , Sun Joo and Jeon، نويسنده , , Tae Hong and Min، نويسنده , , Im Sook and Kim، نويسنده , , In Su and Jung، نويسنده , , Young Hoon، نويسنده ,
Abstract :
A concise asymmetric total synthesis of (S)-dapoxetine from commercially available 3-chloropropiophenone is described. The key step includes a highly stereoselective amination of chiral benzylic ether, with the retention of stereochemistry, using chlorosulfonyl isocyanate.
Keywords :
Dapoxetine , Chlorosulfonyl isocyanate , amination , asymmetric
