Title of article :
High-speed microwave assisted synthesis of SEA0400—a selective inhibitor of the Na+/Ca2+ exchanger
Author/Authors :
de la Cruz، نويسنده , , Gemma Guedes and Groschner، نويسنده , , Klaus and Oliver Kappe، نويسنده , , C. and Glasnov، نويسنده , , Toma N. Glasnov، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
An efficient and rapid five-step synthesis of SEA0400, a selective Na+/Ca2+ exchanger (NCX) inhibitor, using controlled microwave heating is reported. In addition, a novel three-step route omitting the key Baeyer–Villiger oxidation/hydrolysis sequence has been developed.
Keywords :
Baeyer–Villiger oxidation , Williamson ether synthesis , Microwave-assisted synthesis , Continuous-flow hydrogenation , Process intensification , SEA0400
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
