Title of article
A novel and efficient synthesis of Entecavir
Author/Authors
Liu، نويسنده , , Xiaoyu and Jiao، نويسنده , , Xiaozhen and Wu، نويسنده , , Qian and Tian، نويسنده , , Chengsen and Li، نويسنده , , Renze and Xie، نويسنده , , Ping، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
3805
To page
3807
Abstract
A practical synthesis of Entecavir (1) has been accomplished in 10 steps with 21% overall yield. The key steps to construct the five-membered carbocyclic framework 2 are a ring-closing metathesis and a diethyl-aluminum 2,2,6,6-tetramethyl piperidide (DA-TMS) mediated epoxide isomerization. Furthermore, the guanine was introduced by modified Mitsunobu reaction.
Keywords
Epoxide isomerization , Carbacyclic framework , Entecavir , Mitsunobu reaction
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881262
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