Title of article
Synthesis of tetra-substituted pyrroles, a potential phosphodiesterase 4B inhibitor, through nickel(II) chloride hexahydrate catalyzed one-pot four-component reaction
Author/Authors
Khan، نويسنده , , Abu T. and Lal، نويسنده , , Mohan and Ray Bagdi، نويسنده , , Prasanta and Sidick Basha، نويسنده , , R. and Saravanan، نويسنده , , Parameswaran and Patra، نويسنده , , Sanjukta، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
6
From page
4145
To page
4150
Abstract
A wide variety of tetra-substituted pyrrole derivatives were synthesized through one-pot four-component condensation reaction of aromatic aldehydes, benzylamines, β-ketoesters, and nitroalkanes in the presence of 10 mol % NiCl2·6H2O in good yields. Some of them exhibit properties as potential inhibitors of phosphodiesterase 4B (PDE4B) through docking studies.
Keywords
multicomponent reactions , Nickel(II) chloride hexahydrate , Tetra-substituted pyrroles , ?-Ketoesters , Docking studies , Phosphodiesterase 4B inhibitor
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881438
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