Title of article
4′-Methylbiphenyl-2-carbonitrile synthesis by continuous flow Suzuki–Miyaura reaction
Author/Authors
Estrada، نويسنده , , Gizelda O.D. and Flores، نويسنده , , Marcella C. and da Silva، نويسنده , , Joaquim F.M. and de Souza، نويسنده , , Rodrigo O.M.A. and e Miranda، نويسنده , , Leandro S.M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
4166
To page
4168
Abstract
In the present work we report a high selective synthesis of the bicyclic core present in an important angiotensin II inhibitor family of drugs (Sartans) under continuous flow conditions. The key step in our approach was a Suzuki–Miyaura coupling using for the first time the recently described 4-toluylboronic acid MIDA ester.
Keywords
Sartan , 4-Toluylboronic acid MIDA ester , Suzuki–Miyaura cross-coupling , Continuous flow
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881443
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