Author/Authors :
Makarieva، نويسنده , , Tatyana N. and Tabakmaher، نويسنده , , Ksenya M. and Guzii، نويسنده , , Alla G. and Denisenko، نويسنده , , Vladimir A. and Dmitrenok، نويسنده , , Pavel S. and Kuzmich، نويسنده , , Alexandra S. and Lee، نويسنده , , Hyi-Seung and Stonik، نويسنده , , Valentin A.، نويسنده ,
Abstract :
New pentacyclic guanidine alkaloids, monanchomycalins A (1) and B (2) were isolated from the marine sponge, Monanchora pulchra and their structures elucidated using NMR, HRMALDI-TOF-MS, and HRESI MS, as well as by chemical transformations of 1. Compounds 1 and 2 exhibited potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 120 and 140 nM, respectively.
Keywords :
Pentacyclic guanidine alkaloids , Monanchomycalins , spermidine , Marine sponge , Monanchora pulchra
