Author/Authors :
Takamura، نويسنده , , Hiroyoshi and Tsuda، نويسنده , , Kosuke and Kawakubo، نويسنده , , Yohei and Kadota، نويسنده , , Isao and Uemura، نويسنده , , Daisuke، نويسنده ,
Abstract :
Stereoselective synthesis of the C94–C104 fragment of symbiodinolide which is a polyol marine natural product with a molecular weight of 2860 has been accomplished. The synthetic route features Achmatowicz rearrangement and RuO4-catalyzed dihydroxylation for the construction of the tetrahydropyran moiety and the dithiane addition to the aldehyde for the introduction of the side chain.
Keywords :
Polyol marine natural product , Symbiodinolide , Achmatowicz rearrangement , Dithiane addition
