Author/Authors :
Hioki، نويسنده , , Hideaki and Matsushita، نويسنده , , Kimihito and Noda، نويسنده , , Takeshi and Yamaguchi، نويسنده , , Kota and Kubo، نويسنده , , Miwa and Harada، نويسنده , , Kenichi and Fukuyama، نويسنده , , Yoshiyasu، نويسنده ,
Abstract :
An alkoxyamine linker was applied for the solid-phase synthesis of benzothiazoles. The substrate was anchored by aldoxime linkage and products were cleaved from the solid-support by aldoxime–imine exchange coupled with air-oxidation under the weakly acidic conditions. The tether is highly robust under Mitsunobu reaction, nucleophilic substitution reaction, and Pd-catalyzed reaction conditions.
Keywords :
Mitsunobu reaction , benzothiazole , Alkoxyamine linker , Pd-catalyzed reaction , solid-phase synthesis
