Title of article
The Synthesis of 3-pyrazinyl-pyrazolo [1,5-a] pyridines from an enol ether
Author/Authors
Tran-Dube، Michelle B. نويسنده , , Michelle and Sach، نويسنده , , Neal and Ninkovic، نويسنده , , Sacha and Braganza، نويسنده , , John F. and Huang، نويسنده , , Qinhua and Johnson، نويسنده , , Benjamin V.C. Collins، نويسنده , , Michael Raymond، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
4372
To page
4375
Abstract
The synthesis of 3-(6-chloropyrazin-2-yl)pyrazolo[1,5-a]pyridine from an enol ether and 4-substituted 1-aminopyridinim iodides via a 3+2 cycloaddition is presented. A high throughput reaction screen was used to optimize the yield of the cycloaddition. This protocol is operationally simple, scalable, proceeds at room temperature, and the reaction profiles are very clean.
Keywords
5-a]pyridine , 1-Aminopyridinium , Enol ether , 3+2 Cycloaddition
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881532
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