Title of article :
Polyisoprenylated acylphloroglucinols and a polyisoprenylated tetracyclic xanthone from the bark of Calophyllum thorelii
Author/Authors :
Nguyen، نويسنده , , Le-Thu T. and Nguyen، نويسنده , , Hieu T. and Barbi?، نويسنده , , Matej and Brunner، نويسنده , , Gabi and Heilmann، نويسنده , , J?rg and Pham، نويسنده , , Hung D. and Nguyen، نويسنده , , Duc M. and Nguyen، نويسنده , , Lien-Hoa D.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Two new polyisoprenylated acylphloroglucinols, thoreliones A and B, and a new polyisoprenylated tetracyclic xanthone, oxy-thorelione A, together with twelve known compounds, were isolated from the bark of Calophyllum thorelii. The new structures were determined using spectroscopic methods and chemical modification. The major compound thorelione A (1) showed moderate cytotoxic activity against MCF-7, HeLa and NCI-H460 cells with IC50 values of 7.4, 9.3 and 10.6 μg/mL, respectively, using the sulforhodamine B assay.
Keywords :
Polyisoprenylated acylphloroglucinols , Calophyllum thorelii , cytotoxicity , Guttiferae
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
