Title of article :
Regulation off constitutive nitric oxide synthase activity by the human heart
Author/Authors :
Hattler، نويسنده , , Brack G. and Oddis، نويسنده , , Carmine V. and Zeevi، نويسنده , , Adriana and Luss، نويسنده , , Hartmut and Shah، نويسنده , , Nish and Geller، نويسنده , , David A. and Billiar، نويسنده , , Timothy R. and Simmons، نويسنده , , Richard L. and Finkel، نويسنده , , Mitchell S.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
3
From page :
957
To page :
959
Abstract :
We and others have provided indirect evidence for the presence of a constitutive nitric oxide synthase (cNOS) in the mammalian heart. We now provide more direct evidence for the regulation of a myocardial cNOS in the hearts of patients undergoing elective cardiopulmonary bypass (CPB). cNOS enzyme activity was demonstrable in both cytosolic (8.3 ± 0.02 pmol/min/mg) and membrane (11.1 ± 0.4 pmol/min/mg) preparations derived from human atrial pectinate muscles obtained at the rime of CPB (n = 6). Plasma nitrite (NO2−) + plasma nitrate (NO3−) levels from the beating hearts of patients before bypass were reduced from 146 ± 33 to 5.1 ± 50 pmol/min/g after cardiac arrest during CPB (n = 23; p < 0.002 by Studentʹs t test). Thus, the human myocardium constitutively produces nitric oxide that is regulated by the contractile state of the heart.
Journal title :
American Journal of Cardiology
Serial Year :
1995
Journal title :
American Journal of Cardiology
Record number :
1881673
Link To Document :
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