Title of article
Synthesis of novel pyrazole derivatives incorporating one dicarba-closo-dodecaborane unit
Author/Authors
Vلzquez، نويسنده , , Naiara and Gَmez-Vallejo، نويسنده , , Vanessa and Llop، نويسنده , , Jordi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
4743
To page
4746
Abstract
Boron clusters, and especially dicarba-closo-dodecaboranes, can be used as hydrophobic pharmacophores in the design of new drugs. In the current letter, analogs of the CB1 receptor inverse agonist Rimonabant incorporating a carborane cage (either ortho- or meta-carborane) have been synthesized in moderate yields and their structure has been elucidated by means of 1H NMR, 13C NMR, 11B NMR, and HPLC-MS.
Keywords
CB1 receptor , Carborane , Pyrazole
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881684
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