Zeise’s dimer-catalyzed regioselective hydration of homopropargyl tertiary ether

The regioselective hydroalkoxylation of homopropargyl tertiary ether catalyzed by Zeise’s dimer was realized. The desired products were obtained in 61–95% yield with good regioselectivity. This methodology represents a valuable alternative to the aldol reaction or the oxa-Michael reaction to form prochiral tertiary β-hydroxy ketones.