The molecular biology of prostate cancer morbidity and mortality: Accelerated death from ejaculate poisoning?

The molecular biology of host-tumor interactions unique to human prostate cancer that cause patient morbidity are poorly understood despite the prevalence of this neoplasm. Little is known fundamentally about prostate-specific exocrine gene products secreted by metastatic prostate carcinoma cells at metastatic sites that cause diffuse bone pain, immunosuppression, anemia, cachexia, and other clinical signs of advanced prostate cancer. Growing evidence supports the presence of androgen-regulated exocrine gene products as independent mediators of prostate cancer morbidity. The experimental and clinical implications of a hypothesis that prostate-specific exocrine genes cause patient morbidity are discussed.