Title of article
Design and synthesis of a new coumarin-based ‘turn-on’ fluorescent probe selective for Cu+2
Author/Authors
Garcيa-Beltrلn، نويسنده , , Olimpo and Mena، نويسنده , , Natalia and Friedrich، نويسنده , , Leidi C. and Netto-Ferreira، نويسنده , , José Carlos and Vargas، نويسنده , , Vيctor and Quina، نويسنده , , Frank H. and Nٌْez، نويسنده , , Marco T. and Cassels، نويسنده , , Bruce K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5280
To page
5283
Abstract
The novel coumarin-based ‘turn-on’ fluorescent probe (E)-3-(2,5-dimethoxybenzylideneamino)-7-hydroxy-2H-chromen-2-one (MGM) was designed, synthesized, and characterized. This compound shows high selectivity for Cu+2, combined with a large fluorescence enhancement upon binding to Cu2+. Benesi–Hildebrand and Job plots demonstrate that the stoichiometry of the Cu2+ complex formed is 2:1. Preliminary studies employing epifluorescence microscopy demonstrated that Cu+2 could be imaged in human neuroblastoma SH-SY5Y cells treated with MGM.
Keywords
Cu+2 ion , Turn-on probes , Coumarin Schiff base , Fluorescence sensor
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882086
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