Title of article
Efficient synthesis of prasugrel, a novel P2Y12 receptor inhibitor
Author/Authors
Pan، نويسنده , , Xianhua and Huang، نويسنده , , Rui and Zhang، نويسنده , , Jianshui and Ding، نويسنده , , Liping and Li، نويسنده , , Weijin and Zhang، نويسنده , , Qunhui and Liu، نويسنده , , Feng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
5364
To page
5366
Abstract
An efficient synthesis of prasugrel, a novel P2Y12 receptor inhibitor, is described. The cyclopropyl-phenylethanone intermediate was prepared by cyanide substitution, bromination, N-substitution, and the Grignard reaction. After acid hydrolyzation of the methyl ether and subsequent acetylation, the title product was obtained with a total yield of 21% after 10 linear steps from simple and commercially available raw materials.
Keywords
prasugrel , cyclopropyl , platelet inhibitor , Grignard reaction , Synthesis
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882151
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