Title of article :
Multi-gram synthesis of a porphyrazine platform for cellular translocation, conjugation to Doxorubicin, and cellular uptake
Author/Authors :
Trivedi، نويسنده , , Evan R. and Blumenfeld، نويسنده , , Carl M. and Wielgos، نويسنده , , Todd and Pokropinski، نويسنده , , Sharon and Dande، نويسنده , , Prasad and Hai، نويسنده , , Ton T. and Barrett، نويسنده , , Anthony G.M. and Hoffman، نويسنده , , Brian M.، نويسنده ,
Abstract :
We report the synthesis of the near infrared (NIR) fluorescent porphyrazine (Pz) 285, with pendant hydroxyl groups, as a non-toxic platform for delivery of conjugated chemotherapeutic agents to tumor cells. Conjugation of Pz 285 to Doxorubicin via an acid labile linker and initial biological studies are reported.
