Title of article :
A highly regioselective azidolysis of 2,3-epoxy amines: an unexpected [Ti(O-i-Pr)2(N3)2] mediated C-2 opening
Author/Authors :
Righi، نويسنده , , Giuliana and Antonioletti، نويسنده , , Roberto and Pelagalli، نويسنده , , Romina، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
The Lewis acid-catalysed regioselective azidolysis of 2,3-epoxy amines has been investigated. The results obtained demonstrated that using TMSN3 as a source of azide, the appropriate choice of Lewis acid allowed to direct the regiochemistry of the ring opening. The present methodologies provide a powerful tool in organic synthesis for the preparation of diaminoalcohol moieties.
Keywords :
azidolysis , Epoxy amines , regioselectivity , Ring opening , Lewis acids
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
