Title of article :
Chemo- and regioselective modification of adenosine with tertiary cyanopropargylic alcohols
Author/Authors :
Trofimov، نويسنده , , Boris A. and Nosyreva، نويسنده , , Valentina V. and Shemyakina، نويسنده , , Olesya A. and Mal’kina، نويسنده , , Anastasiya G. and Albanov، نويسنده , , Alexander I.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Adenosine reacts with tertiary cyanopropargylic alcohols under mild conditions (K2CO3, DMF, 20–25 °C, 4–30 h) with 100% chemo- and regioselectivity by the way of two vicinal hydroxy groups of the ribose moiety to afford (in 52–72% yield) a novel family of adenosine cyclic ketals possessing cyano and hydroxyalkyl functions.
Keywords :
Tertiary cyanopropargylic alcohols , cyclization , Adenosine cyclic ketals , nucleophilic addition , adenosine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
