Malignant mesothelioma of the male genital tract: report of two cases

Two patients with urogenital mesothelioma are presented. The first patient had a malignant epithelial mesothelioma involving the scrotum and the peritoneal cavity. This patient was treated by extensive surgery and intraperitoneal perioperative chemotherapy; he is well and alive 62 months after diagnosis. The second patient had an aggressive malignant epithelioid mesothelioma of the tunica vaginalis testis; he died 24 months after diagnosis, with locoregional and metastatic recurrent disease, in spite of surgical and systemic chemotherapy treatment. Calretinin immunostains were positive in the first case and negative in the second. Eighty-eight previously published cases of malignant mesothelioma of the tunica vaginalis testis were found in a review of the literature to date. Mesothelioma of the tunica vaginalis testis usually presents as a scrotal mass, thus requiring urologist skills for first line treatment. A multidisciplinary approach is advised when dealing with the malignant form, considering its aggressive natural history.