Author/Authors :
Xiong، نويسنده , , Hui and Wu، نويسنده , , Ye and Lehr، نويسنده , , Scott G. and Blackwell، نويسنده , , William and Steelman، نويسنده , , Gary and Hulsizer، نويسنده , , Jim and Urbanek، نويسنده , , Rebecca A.، نويسنده ,
Abstract :
The development of an efficient and scalable synthetic route to prepare the selective D2 partial agonist (1) is described here. Regioselective nitration of tetrahydrobenzazepine 2, followed by reductive amination, hydrogenation, and oxidative cyclization afforded 1 in good yield, without the need of column chromatography.
Keywords :
heterocycle synthesis , Benzothiazole synthesis , D2 partial agonist , Process route
