Title of article
Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist
Author/Authors
Xiong، نويسنده , , Hui and Wu، نويسنده , , Ye and Lehr، نويسنده , , Scott G. and Blackwell، نويسنده , , William and Steelman، نويسنده , , Gary and Hulsizer، نويسنده , , Jim and Urbanek، نويسنده , , Rebecca A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5833
To page
5836
Abstract
The development of an efficient and scalable synthetic route to prepare the selective D2 partial agonist (1) is described here. Regioselective nitration of tetrahydrobenzazepine 2, followed by reductive amination, hydrogenation, and oxidative cyclization afforded 1 in good yield, without the need of column chromatography.
Keywords
heterocycle synthesis , Benzothiazole synthesis , D2 partial agonist , Process route
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882443
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