Title of article
Convenient syntheses of novel 1-isothiocyano-alkylphosphonate diphenyl ester derivatives with potential biological activity
Author/Authors
Psurski، نويسنده , , Mateusz and Pigu?a، نويسنده , , Marta and Ciekot، نويسنده , , Jaros?aw and Winiarski، نويسنده , , ?ukasz and Wietrzyk، نويسنده , , Joanna and Oleksyszyn، نويسنده , , J?zef، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
5845
To page
5847
Abstract
Herein, we describe a convenient method for the syntheses of novel 1-isothiocyano-alkylphosphonate diaryl ester derivatives and their antiproliferative activity. The syntheses are based on dithiocarbamates obtained in situ with the use of carbon disulfide under basic conditions, and their desulfurization using several different reagents, of which hydrogen peroxide proved to be the most efficient. The compounds synthesized demonstrated high antiproliferative activity against several cancer cell lines in vitro, and also showed some activity as serine protease inhibitors.
Keywords
Isothiocyanates , Phosphonate diaryl esters , Antiproliferative activity , Serine protease inhibition
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882452
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