Title of article
Optimization of Grignard ring-opening of α-brominated dioxolanes for the preparation of β-hydroxy-protected vinyl ethers by a three-step one-pot procedure
Author/Authors
André، نويسنده , , Mathieu and Letribot، نويسنده , , Boris and Bayle، نويسنده , , Martine and Mounetou، نويسنده , , Emmanuelle and Chezal، نويسنده , , Jean-Michel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
6107
To page
6110
Abstract
Aliphatic, cyclic, and aromatic benzoate-protected γ-hydroxy enol ethers were prepared from α-brominated dioxolanes by a three-step reaction procedure and a one-pot protocol involving Grignard reagent formation, ring-opening, and final benzoate protection. Additionally, tert-butyldiphenylsilyl, acetate, and 4,4′-dimethoxytrityl were also successfully used as alternative protecting groups.
Keywords
Grignard reaction , Dioxolane ring-opening , Vinyl ethers , ?-Brominated dioxolanes , Enol ethers
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882614
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