Title of article
A facile and efficient synthesis of 2,2,2-trifluoroethyl 2-[(E)-N-phenylcinnamamido]-2-phenylacetates in trifluoroethanol via sequential Ugi four-component reaction/esterification
Author/Authors
Balalaie، نويسنده , , Saeed and Motaghedi، نويسنده , , Hassan and Tahmassebi، نويسنده , , Daryoush and Bararjanian، نويسنده , , Morteza and Bijanzadeh، نويسنده , , Hamid Reza، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
6177
To page
6181
Abstract
We describe an efficient approach for the synthesis of N-substituted 2-alkenylamides in trifluoroethanol via an Ugi 4-component reaction in short reaction times. The use of a catalytic amount of sulfuric acid in trifluoroethanol gave the desired trifluoroethyl derivatives in good to high yields.
Keywords
Sequential Ugi-4CR/trifluoroethyl esterification , Trifluoroethanol , Ugi-4CR
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882639
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