Title of article
Muchimangins A–D: novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata
Author/Authors
Dibwe، نويسنده , , Dya Fita and Awale، نويسنده , , Suresh and Kadota، نويسنده , , Shigetoshi and Tezuka، نويسنده , , Yasuhiro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
6186
To page
6190
Abstract
Four new highly oxygenated xanthones, named muchimangins A–D (1–4), with a diphenylmethyl substituent have been isolated as extremely minor constituents from the root of Securidaca longepedunculata (Polygalaceae). Among them, muchimangin B (2) induced an apoptotic-like cell death of human pancreatic cancer PANC-1 cell line preferentially in nutrient deprived condition with PC50 of 38.9 μM.
Keywords
Securidaca longepedunculata , Preferential cytotoxicity , Congolese medicinal plant , Xanthone , pancreatic cancer
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882642
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