Cobalt-catalyzed alkyne–dihalomethane–amine coupling: an efficient route for propargylamines

A cobalt-catalyzed three-component coupling of terminal alkynes, dihalomethanes, and amines was developed. This method offers an efficient way for propargylamines via the dual activation of C–H and C–halogen bond. The reaction uses cheap CoBr2 as catalyst and is phosphine ligand-free. A wide range of functional groups were found to tolerate the reaction conditions.