Title of article
Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans and its application to the formal total synthesis of (−)-quinocarcinamide
Author/Authors
Chiba، نويسنده , , Hiroaki and Sakai، نويسنده , , Yuki and Oishi، نويسنده , , Shinya and Fujii، نويسنده , , Nobutaka and Ohno، نويسنده , , Hiroaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
6273
To page
6276
Abstract
An unusual Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans is described. The fused tricyclic ring system is the key structural element for this reaction as it restricts C–N bond rotation and/or destabilizes the benzofuran ring. We achieved the formal total synthesis of (−)-quinocarcinamide using a combination of this reaction and the Au(I)-catalyzed 6-endo-dig hydroamination of an alkyne
Keywords
(?)-Quinocarcinamide , Lewis acid , Dihydrobenzofuran , Ring-exchange
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882681
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