Efficient synthesis of novel tetrahydropyrrolo[3′,4′:3,4]pyrrolo[2,1-a] isoquinoline derivatives via a simple and convenient MCR in aqueous micellar system

A simple and efficient one-pot three component synthesis of tetrahydropyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-9,11-dione derivatives has been achieved from variously substituted isoquinolines, 2-bromo acetophenone and N-aryl maleimide derivatives in an aqueous micellar medium. The synthesis represents an environmentally benign alternative to classical methods.