Title of article
A concise preparation of the non-proteinogenic amino acid l-kynurenine
Author/Authors
Kleijn، نويسنده , , Laurens H.J. and Müskens، نويسنده , , Frederike M. and Oppedijk، نويسنده , , Sabine F. and de Bruin، نويسنده , , Gerjan and Martin، نويسنده , , Nathaniel I.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
6430
To page
6432
Abstract
A concise and practical preparation of the non-proteinogenic amino acid l-kynurenine is reported. The synthetic approach is scalable and provides ready access to this valuable amino acid in either l- or d-stereochemistry starting from l- or d-tryptophan, respectively. In the optimized procedure, two discreet oxidation steps are applied sequentially to convert the tryptophan indole ring into the keto-aniline moiety contained within the kynurenine side chain.
Keywords
Tryptophan oxidation , Oxindolylalanine , Kynurenine , CNS disease
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882768
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