Cu(acac)2 catalyzed oxidative C–H bond amination of azoles with amines under base-free conditions

This work reports a simple and efficient methodology for oxidative C–H bond amination of azoles with aromatic/aliphatic amines using copper-bis-acetylacetonate complex catalyst. The catalyst works very well in the absence of external acid or base and requires only molecular oxygen as an oxidant. The methodology is applicable for the oxidative C–H bond amination of various azoles with different types of aromatic/aliphatic amines for the synthesis of various aminoheterocycles with good to excellent yields.