Ruthenium-catalyzed olefin metathesis after tetra-n-butylammonium fluoride-mediated desilylation

One-pot procedures expedite organic synthesis but pose challenges in that many reagents must be compatible with each other. We discovered that the presence of nBu4NF hindered ruthenium-catalyzed olefin metathesis when nBu4NF-mediated desilylation and olefin metathesis were performed in one pot. This problem could be solved by the addition of (TMS)2O to remove fluoride anions in order to facilitate the ruthenium-catalyzed olefin metathesis.