Title of article :
The first asymmetric total syntheses of 3((1R,2R)- and 3((1S,2R)-2-(12-methyltridecyl)cyclopropyl)propanoic acid
Author/Authors :
Mohapatra، نويسنده , , Debendra K. and Guguloth، نويسنده , , Nagesh and Yadav، نويسنده , , J.S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
The first efficient total syntheses of 3((1R,2R)- and 3((1S,2R)-2-(12-methyltridecyl)cyclopropyl)propanoic acid have been achieved following a chelation controlled modified Simmon–Smith cyclopropanation, Wittig reaction, Horner–Wadsworth–Emmons olefination, and p-toluenesulfonyl hydrazide catalyzed hydrogenation as key reactions in good overall yield.
Keywords :
Cyclopropane fatty acid , asymmetric synthesis , Simmon–Smith cyclopropanation , Horner–Wadsworth–Emmons olefination , Wittig reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
