Title of article
The first asymmetric total syntheses of 3((1R,2R)- and 3((1S,2R)-2-(12-methyltridecyl)cyclopropyl)propanoic acid
Author/Authors
Mohapatra، نويسنده , , Debendra K. and Guguloth، نويسنده , , Nagesh and Yadav، نويسنده , , J.S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
6718
To page
6720
Abstract
The first efficient total syntheses of 3((1R,2R)- and 3((1S,2R)-2-(12-methyltridecyl)cyclopropyl)propanoic acid have been achieved following a chelation controlled modified Simmon–Smith cyclopropanation, Wittig reaction, Horner–Wadsworth–Emmons olefination, and p-toluenesulfonyl hydrazide catalyzed hydrogenation as key reactions in good overall yield.
Keywords
Cyclopropane fatty acid , asymmetric synthesis , Simmon–Smith cyclopropanation , Horner–Wadsworth–Emmons olefination , Wittig reaction
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882882
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