Title of article
Highly diastereoselective 1,3-dipolar cycloaddition via in situ formed ketimine ylides
Author/Authors
Cheng، نويسنده , , Yu and Liu، نويسنده , , Yanan and Ye، نويسنده , , Jia and He، نويسنده , , Long and Kang، نويسنده , , Tai-Ran and Liu، نويسنده , , Quan-Zhong، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
6775
To page
6778
Abstract
1,3-Dipolar cycloaddition of conjugated unsaturated ketimine ylides was disclosed. The reaction of glycine ester with a series of β,γ-unsaturated keto esters in the presence of catalytic amount of TFA was found to give structurally diverse and functionally enriched pyrrolidine derivatives 3 in up to 88% yield. These processes feature a hydrolysis of glycine ketimine. A preliminary enantioselective version of the transformation was also investigated.
Keywords
3-dipolar cycloaddition , 1 , Ketimine ylides , glycine ester , ? , ?-Unsaturated keto ester
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882928
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