Title of article
The stereoselective total synthesis of (−)-dihydrotetrabenazine
Author/Authors
Siva Senkar Reddy، نويسنده , , N. and Srinivas Reddy، نويسنده , , A. and Yadav، نويسنده , , J.S and Subba Reddy، نويسنده , , B.V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
6916
To page
6918
Abstract
A highly stereoselective synthesis of (−)-dihydrotetrabenazine has been accomplished using (R)-tert-butanesulfinamide as a chiral source. The synthesis involves the allylation of chiral N-sulfinyl imine followed by ring closure of the resulting secondary amide with a tethered halide and the Evans-Aldol reaction as key steps.
Keywords
Allylation of N-sulfinyl imine , Asymmetric syn-Aldol reaction , natural product synthesis , asymmetric synthesis , (R)-tert-Butanesulfinamide
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1883031
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