Title of article
Synthetic utility of Kabachnik–Fields reaction: a convenient one-pot three-component synthesis of N-phenyl isoquinolone-1-phosphonates
Author/Authors
Borse، نويسنده , , Amulrao U. and Patil، نويسنده , , Nilesh L. and Patil، نويسنده , , Mahesh N. and Mali، نويسنده , , Raghao S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
6940
To page
6942
Abstract
A convenient, one-pot three-component synthesis of novel N-phenyl isoquinolone-1-phosphonates (4a–4g) using the Kabachnik–Fields reaction, starting from ethyl 2-(2-formyl-4,5-dimethoxyphenyl) acetate (1) and anilines (2a–2g) is described. The aldehyde (1) on reaction with substituted anilines (2a–2g) and triethyl phosphite in acetonitrile using trifluroacetic acid as catalyst provides N-phenyl isoquinolone-1-phosphonates (4a–4g) in good yields.
Keywords
one-pot synthesis , ?-Aminophosphonates , N-Phenyl isoquinolone-1-phosphonates , Kabachnik–Fields reaction
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1883047
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