Title of article
A facile synthesis of melatonergic antidepressant agomelatine
Author/Authors
Rajesh Kumar and Kandagatla، نويسنده , , Bhaskar and Raju، نويسنده , , Vetukuri Venkata Naga Kali Vara Prasada and Reddy، نويسنده , , Ganta Madhusudhan and Rao، نويسنده , , Sirigiri Chandrakanth and Iqbal، نويسنده , , Javed and Bandichhor، نويسنده , , Rakeshwar and Oruganti، نويسنده , , Srinivas، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
7125
To page
7127
Abstract
Agomelatine was synthesized from 8-aminonaphthalen-2-ol by diazotization-iodination, formylation, C–C bond formation by nitroaldol and Pd/C hydrogenation of β-nitrovinylnaphthalene followed by N-acetylation. The route reported employs readily and commercially viable starting materials and reagents, and can potentially be utilized for process synthesis of agomelatine.
Keywords
?-Nitrovinylnaphthalene , Catalytic hydrogenation , Sandmeyer reaction , Henry reaction , Formylation
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1883179
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