Author/Authors :
Rajesh Kumar and Kandagatla، نويسنده , , Bhaskar and Raju، نويسنده , , Vetukuri Venkata Naga Kali Vara Prasada and Reddy، نويسنده , , Ganta Madhusudhan and Rao، نويسنده , , Sirigiri Chandrakanth and Iqbal، نويسنده , , Javed and Bandichhor، نويسنده , , Rakeshwar and Oruganti، نويسنده , , Srinivas، نويسنده ,
Abstract :
Agomelatine was synthesized from 8-aminonaphthalen-2-ol by diazotization-iodination, formylation, C–C bond formation by nitroaldol and Pd/C hydrogenation of β-nitrovinylnaphthalene followed by N-acetylation. The route reported employs readily and commercially viable starting materials and reagents, and can potentially be utilized for process synthesis of agomelatine.
Keywords :
?-Nitrovinylnaphthalene , Catalytic hydrogenation , Sandmeyer reaction , Henry reaction , Formylation
