Author/Authors :
Iaroshenko، نويسنده , , Viktor O. and Ali، نويسنده , , Sajid and Mkrtchyan، نويسنده , , Satenik and Gevorgyan، نويسنده , , Ashot and Babar، نويسنده , , Tariq Mahmood and Semeniuchenko، نويسنده , , Volodymyr and Hassan، نويسنده , , Zahid and Villinger، نويسنده , , Alexander and Langer، نويسنده , , Peter، نويسنده ,
Abstract :
A concise and efficient approach to a series of chromen-4-ones with fused thiophene ring has been developed using the Suzuki–Miyaura reaction of bromothiophene-2- and 3-carboxylates with 2-methoxyboronic acids and subsequent cyclization of prepared alkyl (2-methoxy)aryl thiophene-2- and 3-carboxylates under the action of BBr3/KOtBu. Starting bromothiophenes are easily obtained from corresponding commercially available aminothiophenes by diazotization/bromination reaction.
Keywords :
Suzuki–Miyaura coupling , Thiophene , Lactonization , Sandmeyer reaction , coumarins
