Author/Authors :
Savegnago، نويسنده , , Lucielli and Vieira، نويسنده , , Aline I. and Seus، نويسنده , , Natلlia and Goldani، نويسنده , , Bruna S. and Castro، نويسنده , , Micheli R. and Lenardمo، نويسنده , , Eder Joمo and Alves، نويسنده , , Diego، نويسنده ,
Abstract :
Herein we describe our results on the synthesis and antioxidant properties of 4-arylchalcogenyl-7-chloroquinolines. This new class of compounds has been synthesized in high yields by the reaction of 4,7-dichloroquinoline with diaryl dichalcogenides using KOH as base, DMSO as solvent at 100 °C under air atmosphere and tolerates a range of substituents in the arylchalcogenyl moiety. The obtained compounds 3a and 3j were screened for in vitro antioxidant activity and the results demonstrated that compound 3j presented a potent antioxidant effect when compared to compound 3a.
Keywords :
Quinolines , antioxidant , Tellurium , Selenium , Organochalcogen compounds
