Title of article
A convenient one-pot synthesis of (R)-2-amino-3,3,3-trifluoro-2-methyl-N-phenylpropanamide derivatives
Author/Authors
Li، نويسنده , , Tian-Wen and Shang، نويسنده , , Pei-Hua and Cheng، نويسنده , , Chang-Mei and Zhao، نويسنده , , Yu-Fen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
134
To page
137
Abstract
A convenient one-pot synthesis of enantiopure (R)-2-amino-3,3,3-trifluoro-2-methyl-N-phenylpropanamide derivatives has been developed. The key step in this synthetic methodology turned out to be the amide formation in which (R)-2-amino-3,3,3-trifluoro-2-methylpropanoic acid hydrochloride was simultaneously protected and activated by Vilsmeier reagent.
Keywords
?-Trifluoromethyl-?-amino acids , Amide formation , One-pot , Vilsmeier reagent
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883293
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