Title of article
Synthesis of lactams using enzyme-catalyzed aminolysis
Author/Authors
Stavila، نويسنده , , E. and Loos، نويسنده , , K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
370
To page
372
Abstract
The formation of ε-caprolactam from 6-aminocaproic acid catalyzed by CALB (N435) is reported. Different lactam ring sizes can be prepared starting from 4-aminobutanoic acid, 5-aminovaleric acid, and 8-aminooctanoic acid. Experiments with mixtures of aminocarboxylic acids have shown that CALB prefers homocyclization of the individual aminocarboxylic acids.
Keywords
Ring-closure , Lipase , Lactam , Aminocarboxylic acid
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883495
Link To Document