Title of article :
Efficacy and Tolerability of Lovastatin in 459 African-Americans With Hypercholesterolemia
Author/Authors :
Prisant، نويسنده , , Michael L and Downton، نويسنده , , Maria and Watkins، نويسنده , , Laurence O and Schnaper، نويسنده , , Harold and Bradford، نويسنده , , Reagan H and Chremos، نويسنده , , Athanassios N and Langendِrfer، نويسنده , , Alexandra، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Pages :
5
From page :
420
To page :
424
Abstract :
A paucity of substantive data from clinical drug trials is available specifically evaluating the effects of therapy for hypercholesterolemia in African-Americans, even though a substantial number are candidates for medical advice and intervention for high blood cholesterol. The efficacy and safety of lovastatin in 459 African-Americans with hypercholesterolemia were studied in the Expanded Clinical Evaluation of Lovastatin study, a multicenter, double-blind, diet- and placebo-controlled trial. This trial involved 8,245 patients who were randomly assigned, regardless of race, to receive placebo or lovastatin at doses of 20 mg once daily, 40 mg once daily, 20 mg twice daily, or 40 mg twice daily for 48 weeks. Among African-Americans, lovastatin produced sustained, dose-related (p <0.001) decreases in low-density lipoprotein cholesterol (20% to 38%), total cholesterol (14% to 28%), and triglycerides (8% to 15%). From 75% to 96% of African-Americans treated with lovastatin achieved the National Cholesterol Education Program goal of low-density lipoprotein cholesterol <160 mg/dl, and from 33% to 71% achieved the goal <130 mg/dl. The safety profile of lovastatin in African-Americans was generally favorable. A relatively high incidence of creatine kinase levels greater than the upper limit of normal was observed in African-Americans during the study, i.e., 63% in the placebo group and similar levels in lovastatin treatment groups. Lovastatin is highly effective and generally well tolerated as therapy for primary hypercholesterolemia in African-Americans. (Am J Cardiol 1996;78:420–424)
Journal title :
American Journal of Cardiology
Serial Year :
1996
Journal title :
American Journal of Cardiology
Record number :
1883498
Link To Document :
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