Title of article
Efficient synthesis of N-protected amino/peptide Weinreb amides from T3P and DBU
Author/Authors
Sharnabai، نويسنده , , K.M. and Nagendra، نويسنده , , G. and Vishwanatha، نويسنده , , T.M. and Sureshbabu، نويسنده , , Vommina V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
478
To page
482
Abstract
The reaction of Nα-protected amino/peptide acid with N,O-dimethylhydroxylamine hydrochloride in the presence of T3P and DBU to obtain enantiomerically pure Nα-protected amino/peptidyl Weinreb amides in high yields has been described. Fmoc-Ala-Weinreb amide 2a is obtained as single crystal, and its structure was determined through X-ray crystallography.
Keywords
T3P , Weinreb amides , N?-protected amino/peptide acids , DBU
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883528
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