Title of article
1,2,3-Triazoles as leaving groups in purine chemistry: a three-step synthesis of N6-substituted-2-triazolyl-adenine nucleosides and photophysical properties thereof
Author/Authors
Kova?ovs، نويسنده , , Armands and Novosjolova، نويسنده , , Irina and Bizd?na، نويسنده , , ?rika and Bi??ne، نويسنده , , Inga and Skardziute، نويسنده , , Lina and Kazlauskas، نويسنده , , Karolis and Jursenas، نويسنده , , Saulius and Turks، نويسنده , , M?ris، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
850
To page
853
Abstract
A novel three-step approach for the synthesis of N6-substituted-2-(1,2,3-triazol-1-yl)-adenine nucleosides is described. 2,6-Bis-(1,2,3-triazol-1-yl)purine nucleosides are obtained, which undergo regioselective nucleophilic aromatic substitution with amines at C(6). Thus, 1,2,3-triazoles are shown to be good leaving groups in purine chemistry. The title compounds exhibit interesting levels of fluorescence with quantum yields of up to 53%.
Keywords
click chemistry , nucleoside analogs , nucleophilic aromatic substitution , fluorescence , Triazolyl purine derivatives
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883679
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