Title of article :
Bioactive cembranoids from the Red Sea soft coral Sarcophyton glaucum
Author/Authors :
M. Abou El-Ezz، نويسنده , , Rania F. and Ahmed، نويسنده , , Safwat A. and Radwan، نويسنده , , Mohamed M. and Ayoub، نويسنده , , Nahla A. and Afifi، نويسنده , , Manal S. and Ross، نويسنده , , Samir A. and Szymanski، نويسنده , , Pawel T. and Fahmy، نويسنده , , Hesham and Khalifa، نويسنده , , Sherief I. Khalifa، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A chemical investigation of the Red Sea soft coral Sarcophyton glaucum led to the isolation of one new cembranoid diterpene, namely (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene (2), two cembranoid diterpenes isolated from Nature for the first time, (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol (3) and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol (6) as well as three known compounds, sarcophine (1), (+)-7α,8β-dihydroxydeepoxysarcophine (4) and sarcophytolide (5). Structure elucidation was achieved using spectroscopic techniques, including 1D and 2D-NMR and HRMS. Biological activity investigations of the six isolated compounds were undertaken.
Keywords :
Sarcophyton glaucum , Cembranoid diterpenes , (1S , 4R , 13S)-cembra-2E , 7E , 11E-trien-4 , Cytotoxicity against melanoma , 13-diol
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
