Accessing columbianetin-containing natural products via a domino on-water, in-water process

A domino on-water, in-water process has been developed for the rapid and efficient synthesis of (±)-columbianetin. This highlights the operational simplicity of on-water chemistry. The domino process forms the key step in the synthesis of the columbianetin-containing natural products (±)-columbianetin acetate, (±)-zosimin, (±)-libanorin and (±)-angelmarin.