Title of article :
A microwave-mediated catalyst- and solvent-free regioselective Biginelli reaction in the synthesis of highly functionalized novel tetrahydropyrimidines
Author/Authors :
Harikrishnan، نويسنده , , Palani Sokkan and Rajesh، نويسنده , , Stephen Michael and Perumal، نويسنده , , Subbu and Almansour، نويسنده , , Abdulrahman I.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A series of novel ethyl 2-oxo/thio-4-aryl-6-(arylsulfonylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylates has been synthesized regioselectively by the Biginelli reaction of ethyl 3-oxo-4-(arylsulfonyl)butanoate, aromatic aldehyde and urea/thiourea under microwave irradiation and solvent- and catalyst-free conditions.
Keywords :
Biginelli reaction , catalyst-free , solvent-free , green chemistry , Tetrahydropyrimidine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
