Title of article
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides
Author/Authors
Gemma، نويسنده , , Sandra and Kunjir، نويسنده , , Sanil and Brindisi، نويسنده , , Margherita and Novellino، نويسنده , , Ettore and Campiani، نويسنده , , Giuseppe and Butini، نويسنده , , Stefania، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
1233
To page
1235
Abstract
As a part of our work in the development of novel antimalarials, we were interested in elaborating an appropriate synthetic strategy for the preparation of endoperoxide-containing bridged bicyclic scaffolds. Through a TMSOTf-promoted dehydrative cyclization strategy we synthesized 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides. Alkyl substituents at C4 of the bicyclic scaffold could be readily introduced through exposure to Grignard reagents.
Keywords
endoperoxide , lactol , Trimethylsilyl triflate
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883876
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