Author/Authors :
Jalli، نويسنده , , Venkata Prasad and Jaggavarapu، نويسنده , , Satyanarayana Reddy and Kamalakaran، نويسنده , , Anand Solomon and Gangisetty، نويسنده , , Sravan Kumar and Nanubolu، نويسنده , , Jagadeesh Babu and Gaddamanugu، نويسنده , , Gopikrishna، نويسنده ,
Abstract :
A facile protocol for direct access to chromeno-pyrimidine-N-oxides is reported by the reaction of 4-chloro-3-formylcoumarin and aromatic carboximide oximes via tandem double nucleophilic addition and dehydration reactions. The one-pot reaction serves as an alternative protocol for achieving regioselective pyrimidine mono-N-oxide products as pure precipitates in good to excellent yields. The structure of the product was confirmed by X-ray analysis.
Keywords :
Carboximide oxime , tandem , Pyrimidine-N-oxides , 4-Chloro-3-formylcoumarin , Chromeno-pyrimidine-N-oxide
